Formulation and Characterization of Curcumin-Loaded Microsponge Gel for Controlled Release and Enhanced Stability in Topical Antioxidant Therapy
DOI:
https://doi.org/10.69855/farmasi.v2i1.543Keywords:
microsponge, curcumin, topical delivery, antioxidant, controlled release, photostabilityAbstract
Curcumin possesses strong antioxidant and photoprotective activities, but its poor aqueous solubility, limited skin penetration, and high photoinstability restrict topical efficacy. This study developed curcumin-loaded microsponges using Eudragit RS100 by the quasi-emulsion solvent diffusion method. The optimized formulation (MS-F5) showed high encapsulation efficiency (91.7 ± 1.6%), porosity (61.3 ± 2.8%), positive zeta potential (+28.3 ± 2.1 mV), and sustained 24-h drug release following Higuchi kinetics (R² = 0.9952). Incorporated into a 2% Carbopol gel, MS-F5 significantly enhanced skin permeation (2.89-fold), epidermal retention (3.52-fold), antioxidant activity (IC₅₀ 12.4 ± 0.8 vs. 18.7 ± 1.2 µg/mL), and photostability (72.4% vs. 18.3%) compared with plain curcumin gel (p < 0.05). Stability studies following ICH Q1A(R2) and Q1B guidelines confirmed acceptable physicochemical and microbiological stability over six months. These findings demonstrate that microsponge technology improves curcumin stability, controlled release, skin delivery, and antioxidant performance, highlighting its potential for dermatological and cosmeceutical applications.
References
Jakubczyk K, Drużga A, Katarzyna J, Skonieczna-Żydecka K. Antioxidant potential of curcumin a meta-analysis of randomized clinical trials. Antioxidants. 2020;9(11):1092.
Salehi B, Venditti A, Sharifi-Rad M, et al. The therapeutic potential of curcumin: a review of clinical trials. Eur J Med Chem. 2020;209:112932.
Mangolim CS, Moriwaki C, Nogueira AC, et al. Curcumin photodegradation: mechanisms, influencing factors, and the role of encapsulation. Food Chem. 2021;342:128218.
Verma A, Jain A, Tiwari A, Saraf S, Panda PK. Curcumin: a comprehensive review on physicochemical properties, bioavailability, and formulation strategies. Pharmaceutics. 2021;13(12):2085.
Amalina ND, Sari DRT, Meylinda T, et al. Curcumin-loaded nanoparticles: a systematic review of formulation strategies for enhanced topical delivery. J Drug Deliv Sci Technol. 2022;74:103538.
Sutradhar KB, Amin ML. Nanoemulsions: increasing possibilities in drug delivery. Eur J Nanomed. 2021;13(1):11-22.
Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm. 2021;598:120413.
Srivastava R, Kumar D, Pathak K. Colonic luminal surface retention of meloxicam microsponges delivered by erosion based colon targeted matrix tablet. Int J Pharm. 2022;432(1-2):149-160.
Gauthier F, Abdulkarim M, Séchoy O, et al. Eudragit RS100 microspheres for ophthalmic controlled delivery: formulation and in vitro characterization. J Microencapsul. 2022;39(3):201-213.
Damiani G, Pacifico A, Linder DM, et al. Antioxidants and skin photoprotection: from bench to bedside. Antioxidants. 2023;12(4):917.
Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules. 2023;13(3):468.
Hussain Z, Thu HE, Shuid AN, Katas H, Hussain F. Recent advances in polymer-based wound dressings for the treatment of diabetic wound: a systematic review. Curr Pharm Des. 2021;27(30):3266-3285.
Almurshedi AS, Radwan M, Omar S, et al. A novel pH-sensitive liposome for controlled drug release and targeting cancer cells. J Mol Liq. 2021;328:115455.
Patel MK, Bhatt HN, Patel RB, Patel MM. Development and evaluation of microsponge-based drug delivery system for topical application. J Drug Deliv Sci Technol. 2021;63:102481.
Aldawsari HM, Badr-Eldin SM, Labib GS, El-Kamel AH. Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect. Int J Nanomedicine. 2021;16:681-692.
Nair AB, Shah J, Al-Dhubiab BE, et al. Clarithromycin microsponge ophthalmic in situ gel: improved ocular bioavailability. Pharmaceutics. 2021;13(6):895.
Rao MRP, Shelar SU. Controlled release dissolution and ex vivo permeation of itraconazole from a porous microsponge gel. Drug Dev Ind Pharm. 2021;47(3):391-404.
Kenchappa R, Bhatt H, Bhatt D, Bhatt S. Microsponge drug delivery system: a comprehensive review of formulation, characterization, and applications. Futur J Pharm Sci. 2022;8(1):45.
Pund S, Joshi A. Nanoarchitectures for neglected tropical infectious diseases: challenges and solutions. In: Nanostructures for the Engineering of Cells, Tissues and Organs. Academic Press; 2023:587-634.
Rajput AP, Butani SB. Resveratrol anchored nanostructured lipid carrier loaded in situ gel via nasal route: formulation, optimization and in vivo characterization. J Drug Deliv Sci Technol. 2022;68:103048.
Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2021;13(2):123-133.
Bruschi ML, ed. Strategies to Modify the Drug Release from Pharmaceutical Systems. Woodhead Publishing; 2022.
Almeida H, Amaral MH, Lobão P, Lobo JS. Applications of polymeric and lipid nanoparticles in ophthalmic pharmaceutical formulations: present and future considerations. J Pharm Pharm Sci. 2021;17(3):278-293.
Sallam MA, Helal NA, Mortada SM. Rationally designed nanoparticles for skin delivery via a transappendageal route. Int J Nanomedicine. 2020;15:9539-9557.
Suvarna V, Gujar P, Murahari M. Complexation of phytochemicals with cyclodextrins and their derivatives — an update. Biomed Pharmacother. 2022;151:113158.
ICH Q1A(R2). Stability Testing of New Drug Substances and Products. International Council for Harmonisation; 2003.
ICH Q1B. Photostability Testing of New Drug Substances and Products. International Council for Harmonisation; 1996.
ICH Q2(R2). Validation of Analytical Procedures. International Council for Harmonisation; 2022. (diperbarui ke versi R2 terbaru)
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Copyright (c) 2026 Emma Jayanti Besan, Muhammad Nurul Fadel, Nur Masyithah Zamruddin, Husnunnisa, Cut Intan Annisa Puteri
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